Intestinal Alkaline Phosphatase in the colonic mucosa of children with inflammatory bowel disease Running title: intestinal alkaline phosphatase in pediatric IBD
نویسندگان
چکیده
Kriszta Molnár, Áron Cseh, András Arató, Gabor Veres, First Department of Pediatrics, Semmelweis University, H-1083, Budapest, Hungary Ádám Vannay, Beáta Szebeni, Erna Sziksz, Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, H-1083, Budapest, Hungary Nóra Fanni Bánki, SE-MTA “Lendulet” Diabetes Research Group, Budapest, Hungary Hajnalka Győrffy, Second Department of Pathology, Semmelweis University, H-1091, Budapest, Hungary Peter Laszlo Lakatos, First Department of Medicine, Semmelweis University, H-1083, Budapest, Hungary Mária Papp, Second Department of Medicine, University of Debrecen, H-4032, Debrecen, Hungary
منابع مشابه
Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.
AIM To investigate intestinal alkaline phosphatase (iAP) in the intestinal mucosa of children with inflammatory bowel disease (IBD). METHODS Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls. In IBD patients, specimens were obtained both from inflamed and non-inflamed areas. The iAP mRNA and protein expression was determined by reverse transcr...
متن کامل[The role of intestinal alkaline phosphatase in pediatric inflammatory bowel and celiac diseases].
Intestinal alkaline phosphatase enzyme plays a pivotal role in the maintenance of intestinal mucosal barrier integrity with the detoxification capacity of lipopolysaccharide, the ligand of Toll-like receptor 4. The inappropriate immune responses and the damage of the mucosal barrier may contribute to the initiation of inflammatory bowel and celiac diseases. In the inflamed colonic mucosa of chi...
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Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essential for maintaining gut homeostasis has been established. IAP is an important apical brush border enzyme expressed throughout the gastrointestinal tract and secreted both into the intestinal lumen and into the bloodstream. IAP exerts its effects through dephosphorylation of proin...
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Yu Ping Feng San (YPFS), a Chinese herbal decoction comprising Astragali Radix (AR; Huangqi), Atractylodis Macrocephalae Rhizoma (AMR; Baizhu), and Saposhnikoviae Radix (SR; Fangfeng), has been used clinically to treat inflammatory bowel diseases (IBD). Previously, we demonstrated a dual role of YPFS in regulating cytokine release in cultured macrophages. In this study, we elucidated the anti-i...
متن کاملAlkaline phosphatase levels in normal and diseased small bowel.
Since the introduction of peroral biopsy of the small intestine (Shiner, 1956; Crosby and Kugler, 1957) there has been growing interest in intestinal enzymes as well as morphology. The disaccharidases have received most attention, but many other enzymes, including alkaline phosphatase, are present in the small intestinal mucosa. There are few reports on human intestinal alkaline phosphatase and...
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تاریخ انتشار 2012